Using computer simulations, chemists have discovered how nuclear bodies called nucleoli interact with chromosomes in the nucleus, and how those interactions help the nucleoli exist as stable droplets ...

There is a huge amount of DNA in most human cells, and that DNA has to be carefully compacted and organized so that it will fit into a cell’s nucleus, while the crucial parts of it remain accessible ...

University of Alberta researchers have found an answer to a fundamental question in genomic biology that has eluded scientists since the discovery of DNA: Within the nucleus of our cells, is the ...

SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated ...

A cell's nucleus has to hold the entire genome. To do that, the DNA must be carefully arranged and compacted by proteins called histones into a complex known as chromatin. Now scientists have ...

Ultimately, everything is governed by the laws of physics, including gene regulation. Why is it, then, that that the laws of physics are so sparingly consulted when biologists describe chromatin, that ...

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers—about a millionth of a milliliter. The cell manages this by ...

In addition to exporting materials out of the nucleus, the protein, called Exportin-1 (also called Xpo1 or Crm1), seems to play a role in promoting gene transcription, the process that creates RNA ...